Oxygen availability and metabolic reprogramming in cancer
2017
Abstract Hypoxia and dysregulated metabolism are defining features of solid tumors. How cancer cells adapt to low O2 has been illuminated by numerous studies, with "reprogrammed" metabolism being one of the most important mechanisms. This metabolic reprogramming not only promotes cancer cell plasticity, but also provides novel insights for treatment strategies. As the most studied O2 "sensor", hypoxia-inducible factor (HIF) is regarded as an important regulator of hypoxia-induced transcriptional responses. This review will summarize our current understanding of hypoxia-induced changes in cancer cell metabolism, with an initial focus on HIF-mediated effects, and highlight how these metabolic alterations affect malignant phenotypes.
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