Роль HLA-антигенов в формировании атопических заболеваний у детей и подростков московского региона

A considerable leap of HLA system research has occurred lately. Its essence is conversion from investigations of protein HLA molecules to investigations of directly genetic material that determines allelic polymorphism of HLA system. That was possible due to discovery and adoption of the polymerase chain reaction method into clinical and laboratory practice. The results of our own research are presented in the article. Its purpose was to study the HLA system's traits of class I and class II at the population level by the most up-to-date molecular genetics methods in children and adolescents with persistent clinical course of atopic diseases in Moscow region, and to estimate the role of the HLA system in the above-listed pathology's formation. The allelic specificities have been revealed. Their presence testifies to positive or negative association with atopic diseases. The derived data can be used by pediatricians, adolescents physician, allergologists and immunologists in clinical practice to predict atopic development for children burden with hereditary anamnesis, to increase an efficiency of prophylaxis and therapy of atopic pathology, to develop optimal treatment plan taking into account the derived results of complex allergological and the molecular genetics examinations.