Prevalence, Echocardiographic Correlations, and Clinical Outcome of Tricuspid Regurgitation in Patients with Significant Left Ventricular Dysfunction

Abstract Purpose We initiated this study to evaluate the prevalence and clinical significance of tricuspid regurgitation in patients with left ventricular dysfunction. Methods A single-center analysis of all echocardiographic studies between 2000 and 2013 was performed. Patients with ejection fraction Results The study included 3943 patients (74% male, age 69 ± 14 years); 70% had nonsignificant, 24% had moderate, and 6% had severe tricuspid regurgitation. In a multivariate model, tricuspid regurgitation was independently associated with older age (odds ratio [OR] 1.009; 95% confidence interval [CI], 1.001-1.017; P  = .022), female sex (OR 1.644; 95% CI, 1.329-2.035; P P P P 2 , OR 1.031; 95% CI, 1.013-1.049; P P P  = .010) or obesity (OR 0.583; 95% CI, 0.427-0.796; P P Conclusions Significant tricuspid regurgitation is common in patients with left ventricular dysfunction. It is linked to various cardiac pathologies and independently associated with increased mortality.