A Unified Approach to the Enantioselective Synthesis of 2,6-cis and trans Disubstituted Tetrahydropyranones

A stereoselective construction of cis- and trans-2,6-disubstituted tetrahydropyranones, based on strategy which combines an asymmetric alkylation and ring closing metathesis for the formation of a cyclic enol ether, is reported.