Effect Of Vitamin D Supplementation On Stroke Functional Outcome (1653)

Objective: To establish the effect of vitamin D supplementation on stroke functional outcome at 3 months. Background: In recent years, vitamin D deficiency has been reported to be associated with cardiovascular disease including stroke. Low vitamin D levels could be associated with greater morbidity and mortality in stroke patients. Evidence from clinical studies is lacking. Design/Methods: A randomised controlled open-label trial was conducted in the Department of Neurology at the university hospital of Sahloul-Sousse-Tunisia from July 2018 to July 2019. Patients, suffering from acute stroke, were screened for serum 25 hydroxy vitamin D (25(OH)D) levels. Those with baseline 25(OH)D Results: A total of 149 stroke patients were included with mean age± SD of 65.37 ±12.5 years and male female rate ratio 1.67. The median serum 25 (OH) D concentration at admission was 11.35 (IQR, 7.37–17.71) ng/ml. At 3 months, the median serum 25 (OH) D concentration in the supplemented group was 36.9 (IQR 24.7–61.9) ng/ml. Seventy percent of patients had a good functional outcome (mRs Conclusions: Our findings suggest that vitamin D3 supplementation does not improve functional outcome after acute stroke but vitamin D deficiency was associated with severe NIHSS at admission. It needs to be validated by a larger trial. Disclosure: Dr. Jarrar has nothing to disclose. Manel Ben Halima has nothing to disclose. Anis Hassine has nothing to disclose. Sana Ben Amor has nothing to disclose.