Protective effect of low-doses of antibodies to S-100 protein on the formation of long-term sensitization in helix lucorum.

Injection of antibodies to Ca-binding protein S-100 in a dilution of 10−12 before the formation of long-term sensitization in Helix lucorum (10 min before the first electric shock) prevented the increase in defense reactions of pneumostome closure and ommatophore withdrawal. Thus, we demonstrated a protective effect of low-dose antibodies to S-100 on the formation of long-term sensitization as a neurobiological model of anxiety and depression.