Statins inhibit MHC- II expression of thyrocytes from hypothyroid patients with Hashimoto's thyroiditis

采用流式细胞术检测人甲状腺上皮细胞(TEC)MHC-Ⅱ表达,发现桥本甲状腺炎(HT)甲减患者TEC MHC-Ⅱ表达明显高于正常对照[(40.7+5.5)%vs(2.7+2.1)%,P＜0.01],γ干扰素可以显著促进TEC MHC-Ⅱ的表达(P＜0.01),他汀类药物(Simvastatin和Atrovastatin)可显著抑制γ干扰素诱导的TEC MHC-Ⅱ表达(均P＜0.05),从而降低相应的淋巴细胞活化,缓解HT的免疫紊乱。