Genetic association between mood disorder and monoamine oxidase gene

Objective To ascertain whether the mood disorder (bipolar and unipolar) is genetically associated with genes polymorphisms of MAOA type and MAOB type in the Chinese Methods One hundred and thirty two cases of Chinese with mood disorder were genotyped for the MAOA(CA) n, MAOB(GT) n and MAOB(TG) n locus using Amp FLP Results Among 132 cases with mood disorder, 8 alleles (size: 112 126 bp) of MAOA(CA) n, 12 alleles (size: 168 198 bp) of MOAB(GT) n and 9 alleles (size: 195 213 bp) of MAOB(TG) n locus were observed Comparison of the polymorphisms of all alleles in the three locus showed that no significant difference ( P 0 05) was seen in the frequency distribution between cases with mood disorder (bipolar and unipolar) and controls, but the frequency of 180 bp allele for MAOB(GT) n and 250 bp allele for MAOB(TG) n was significantly different ( P 0 05) between the two groups Conclusion MAO gene (type A and B) is not associated with mood disorder in the Chinese