Antibiotic resistance of Helicobacter pylori in Guizhou Province

Objective To determine the Helicobacter pylori(H.pylori) resistance to multiple antibiotics and the clinical features of antibiotic-resistance patients.Methods 30 H.pylori strains were successfully isolated.Resistance to different antibiotics,including clarithromycin(CLA),amoxicillin(AMO) and metronidazole(MTZ) were determined by Kirby-Bauer and E-test methods.Information of clinical features was gathered.Results Kirby-Bauer results showed 20.00%,3.33%,13.33%,30.00%,6.67%,0,0 of the strains were resistant to AMO,levofloxcin,gentamicin,CLA,tetracycline,cefuroxime or SMZ-TMP respectively.E-test results manifested that 63.33%,26.67%,33.33% of the strains were resistant to MTZ,AMO or CLA respectively.The resistance rate of H.pylori to MTZ in male patients(77.78%) was higher than that in female patients(41.67%)(P0.05).The resistance rate of H.pylori to MTZ in patients with peptic ulcer(84.62%) was higher than that in patients with erosive gastritis(27.27%)(P0.05).Patients aged 30~60 years old had a higher resistance rate to MTZ than other groups(P0.05).There was no significant difference in CLA and AMO resistance rate among sex ages or disease.Conclusion Resistance of H.pylori to antibodies should be pay more concern in Guizhou province.Resistant rate of H.pylori to MTZ is the highest compared with other antibodies,especially in male patients with peptic ulcer around 30~60 ages.