DIKETOPIPERAZINE DERIVATIVES, A NEW SERIES OF PLATELET-ACTIVATING FACTOR INHIBITORS

Norihiko Shimazaki,Ichiro Shima,Keiji Hemmi,Yasuhisa Tsurumi,Masashi Hashimoto

DIKETOPIPERAZINE DERIVATIVES, A NEW SERIES OF PLATELET-ACTIVATING FACTOR INHIBITORS

1987

Norihiko Shimazaki
Ichiro Shima
Keiji Hemmi
Yasuhisa Tsurumi
Masashi Hashimoto

Some diketopiperazine derivatives (3a-f, 4a-f, and 5a-c) related to natural products (1 and 2) have been prepared and evaluated for their inhibition of platelet aggregation induced by platelet-activating factor (PAF).

Keywords:

Cyclic peptide
Structure–activity relationship
Lactam
Stereochemistry
Platelet Activating Factor Inhibitors
Biological activity
Dipeptide
Platelet
Organic chemistry
Platelet-activating factor
Biochemistry
Chemistry
platelet aggregation

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