TMOD-05. C-MYC OVEREXPRESSION INDUCES CHOROID PLEXUS PAPILLOMAS THROUGH A T-CELL MEDIATED INFLAMMATORY MECHANISM

Choroid plexus tumours (CPTs) account for 2–5% of brain tumours in children. They can spread along the neuraxis and can recur after treatment. Little is known about the molecular mechanisms underlying their formation and only few high fidelity mouse models of p53-deficient malignant CPTs are available.