Antibacterial and antioxidant activity of three com pounds isolated from Mitracarpus scaber

The antibacterial and the free radical scavenging a ctivities of the alcoholic extract, total alkaloid extract and three compounds isolated from Mitracarpus scaber were evaluated using the p-iodonitrotetrazolium method and the DPPH method. The extracts and the three compounds identified as methoxy-4-acetophenon, 3,4,5-trimethoxybenzoic acid, azaanthraquinone were tested in vitro against five micro organisms. Azaanthraquinone showed the most interesting activi ty with minimum inhibitory concentrations values of 7.5 µg/ml, 19 µg/ml, 38 µg/ml and 150 µg/ml on Dermatophilus congolensis, Staphylococcus aureus , Enteroccocus feacalis , Escherichia coli and Pseudomonas aeruginosa, respectively. On the other hand, the three tested compounds showed mild scavenging activity in the DPPH test, with IC 50 values between 12 µg/ml and 45.74 µg/ml. © 2010 International Formulae Group. All rights res erved.