Correlation between basal serum IGF-1 levels and functional Correlation between basal serum IGF-1 levels and functional autonomy in elderly women. autonomy in elderly women. Correlación entre los niveles sericos de IGF-1 basal y Correlación entre los niveles sericos de IGF-1 basal y autonomía funcional en ancianas. autonomía funcional en ancianas.

The aim of the present study was to determine the degree of correlation between basal serum IGF-1 levels and functional autonomy in the performance of activities of daily living (ADL). The sample comprised 11 elderly individuals, disregarding their ADLs (age = 68.18 ± 5.19 years; body mass index (BMI) = 28.89 ± 3.44 kg/m2) and not enrolled in physical exercise programs for at least 3 months. The subjects were submitted to a battery of 5 functional autonomy tests from the GDLAM protocol and blood collection to assess serum IGF-1 levels. Using Pearson’s correlation, we found a significant mean correlation coefficient (r) between the 10 m walking test (10mW) and IGF-1 (r = -0.690; p = 0.009) and mean correlation, but not significant between the putting on and removing a t-shirt test (PRTS) and IGF-1 (r = -0.528) and between the general autonomy index (AI) and IGF-1 (r = -0.417). The correlation was low in the remaining tests, but inversed. This suggests that the decline in IGF-1 with age may decrease ADL performance in the elderly.