Animal experience of percutaneous venous-venous extracorporeal membrane oxygenation

Objective To investigate the effect of percutaneoous venous-venous extracorporeal membrane oxygenation(V-V ECMO) in canine acute lung injury (ALI).Methods Six canines underwent ALI with the injection of oleic acid 0.1ml/kg. The device of V-V ECMO connected with 17Fr cannular inserted through right jugular vein and 10Fr cannular inserted through right femoral vein. The arterial blood gas parameters were recorded before injection of oleic acid, after ALI, ECMO 2h, ECMO 4h. Results ALI appeared after injection of oleic acid 4-6h lately. Aterial oxygen tension was 98±7 mmHg and oxygen saturation was 95.5±2.2% at ECMO 2h. At ECMO 4h arterial oxygen tension was 67±3 mmHg and oxygen saturation was 92.3±2.2%. The carbon dioxide tension of artery during ECMO was lower (P0.05).Conclusion Oxygen is taken in efficiently and carbon dioxide is given out in ALI via percutaneous V-V ECMO, so the conventional ventilator mode can be modified.