Inflammation,immune system activation and coronary heart disease

Objective To assess the correlation between inflammation,specific immune response and coronary heart disease(CHD). Methods Thirty healthy cases passed the health examination were taken as the control group. Eighty cases who were diagnosised into CHD,affirmed by coronary angiography,were divided into three groups: acute myocardial infarction (AMI) group(26 cases),unstable angina pectoris (UP) group (24 cases),and stable angina pectoris (SP) group(30 cases). All the cases were tested on the concentrations of C-reactive protein(CRP),IgA,IgG,IgM in serum. Results The serum indices of CRP,IgG,IgA in AMI group and UP group were significantly difference than those in the control group (P0.05),but there was no significant difference in the indices of IgM in UP group,SP group and AMI group,and the indices of CRP,IgG of the SP group than that in the control group (P0.05). Conclusion The correlation between inflammation and immune system activation are closely associated with CHD.