Research in the imidazole series. 93. Synthesis of derivatives of benzimidazolyl-1-acetic acid

A simple method has been developed for obtaining esters of benzimidazolyl-1-acetic acid and its 2-alkyl (or aralkyl) derivatives, by reaction of benzimidazoles with esters of chloroacetic or bromoacetic acid in DMF in the presence of anhydrous potassium carbonate. The method of synthesis of amides of these acids has been simplified.