A new role for CD23 in inflammation

Abstract CD23, is expressed on a variety of haematopoietic cell types and displays pleiotropic activities in vitro . Here Jean-Yves Bonnefoy and collegues discuss a novel interaction between CD23 and the α chains of the β 2 integrins, CD11b and CD11c, that leads to a proinflammatory pattern of macrophage activation. They describe how neutralizing antibodies to CD23 can decrease the severity of murine arthritis.