AB0440 Impact of vitamin d deficiency upon disease activity and immune disorder in rheumatoid arthritis patients

Background Emerging evidence suggests that vitamin D plays an important role in immune regulation. Objectives The objective of this work was to determine if patients with rheumatoid arthritis (RA) are at risk for vitamin D deficiency and whether vitamin D levels correlate with disease activity or immune disorders. Methods This study was a retrospective research. RA patients who had vitamin D levels and immune function indexes of each other were included. Patients receiving or have received vitamin D, corticosteroids, disease-modifying anti-rheumatic drugs or a tumor necrosis factor antagonist and those who had hepatic or renal insufficiency were excluded. Multivariate analysis was performed to examine correlations and control for confounding factors. Results As suggested threshold (≤25 ng/ml), the overall prevalence of vitamin D insufficiency was 265 of 280 (94.8%). Mean serum vitamin D insufficiency levels of 11.15±4.74 ng/ml for RA patients were significantly lower compared to controls (31.62±6.46) (p=0.001). Among all the subjects, 208 (72.7%) were females. Vitamin D levels in high disease activity group were lower compared to vitamin D level in patients with low and moderate disease activity (DAS-28 score >5.1, 3.2–5.1, Conclusions Lower levels of vitamin D are associated with worse DAS28 and higher levels of Th17 with RA, especially in female patients. The levels of 1,25-dihydroxycholecalciferol (1,25(OH) 2 D 3 ) could be a marker to monitor the disease activity in RA patients and vitamin D may be an alternative supplementary treatment for RA. Acknowledgements This work was supported by research grants from the National Natural Science Foundation of China (no. 81301532/H0603) and the Shanxi Science and Technology research projects of China (no. 201603D321074). Disclosure of Interest None declared