Naringenin (4,5,7-trihydroxyflavanone) suppresses the development of precancerous lesions via controlling hyperproliferation and inflammation in the colon of Wistar rats
2018
Colon cancer is a world-wide health problem and one of the most dangerous type of cancer,
affecting both men and women. Naringenin (4, 5, 7-trihydroxyflavanone) is one of the major flavone
glycoside present in citrus fruits. Naringenin has long been used in Chinese’s traditional
medicine because of its exceptional pharmacological properties and non-toxic nature. In the present
study, we investigated the chemopreventive potential of Naringenin against 1,2-
dimethyhydrazine (DMH)-induced precancerous lesions, that is, aberrant crypt foci (ACF) and
mucin depleted foci (MDF), and its role in regulating the oxidative stress, inflammation and hyperproliferation,
in the colon of Wistar rats. Animals were divided into five groups. In groups 3-5,
Naringenin was administered at the dose of 50 mg/kg b. wt. orally while in groups 2-4, DMH was
administered subcutaneously in the groin at the dose of 20 mg/kg b. wt. once a week for first
5 weeks and animals were euthanized after 10 weeks. Administration of Naringenin ameliorated
the development of DMH-induced lipid peroxidation, ROS formation, precancerous lesions (ACF
and MDF) and it also reduced the infiltration of mast cells, suppressed the immunostaining of NFjB-
p65, COX-2, i-NOS PCNA and Ki 67 Naringenin treatment significantly attenuated the level of
TNF-a and it also prevented the depletion of the mucous layer. Our findings suggest that Naringenin
has strong chemopreventive potential against DMH-induced colon carcinogenesis but
further studies are warranted to elucidate the precise mechanism of action of Naringenin.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
62
References
23
Citations
NaN
KQI