Dividing Tumors and Topographical Orientation

So far only on examples of small tumors in which the excised tumor specimen fitted completely in the device for histological sectioning were discussed. If tumors are larger due to their advanced growth or larger safety margins, the resulting specimen may not fit completely onto the devices used for histological sectioning. In these cases, the excised specimens have to be divided in parts small enough to be sectioned by either cryo-sectioning or paraffin sectioning raising new complex issues of topographical orientation which will be discussed in the following.