Anticancer Potential of Azole Containing Marine Natural Products: Current and Future Perspectives.

BACKGROUND Despite significant advancement in the oncology research, cancer still poses as one of the leading causes of mortality worldwide. The increased incidences of cancer may be attributed to the limited efficacy and disastrous side effects of the conventional therapies like chemotherapy, radiotherapy and surgery. Azole containing medicinal agents are known for plethora of medicinal properties including anticancer potential. OBJECTIVE In this review, we highlighted azole containing natural products with anticancer potential from marine sources. METHOD A comprehensive literature search was performed for writing the review. Updated views about various marine sponges, cyanobacteria, tunicates and microalgae producing azole nucleus containing secondary metabolites with anticancer potential have been discussed. RESULTS The present article describes the structural, chemical, and biological features of azoles containing natural agents from marine sources with promising anti-cancer potential. Additionally, current challenges and future perspectives of azoles in cancer prevention and treatment are also discussed. CONCLUSION This review might encourage scientific community to explore marine sources for developing novel and potent azole containing anti-cancer agents with better safety profile.