2,4(5)-Diarylimidazoles : Synthesis and biological evaluation of a new class of sodium channel blockers against hNav1.2

Abstract A small family of novel 2,4(5)-diarylimidazoles were prepared through a simple and efficient synthesis and evaluated as potential inhibitors of hNa v 1.2 sodium channel currents. One member of this series ( 4 ) exhibited profound inhibition of Na v 1.2 currents, emerging as a promising lead compound for further structure–activity relationship studies for the development of novel sodium channel blockers.