EFFECT OF NUCLEAR GLYCOPROTEINS ON THE ACTIVITY OF RAT BRAIN ACETYLCHOLINESTE RASE AND GABA- TRANSFERASE

The functional role of the proteins synthesized in the cell nuclei and especially in the nuclei of brain neurons has, on the whole, remained an unsolved problem. According to the hypothesis of a number of researchers, the proteins synthesized in the nuclei are responsible for the growth and differentiation of cells [1] and the decondensation of chromatin [2], and suppress the RNA polymerase activity of the nuclear chromatin [3]. However, there has so far been no concrete answer to the question of the role of the nuclear proteins -- glycoproteins (GPs) -- synthesized. We have previously isolated GPs and studied their physicochemical properties and have begun a study of their functional role [3]. In the present paper we give the results of a study of the effect of nuclear glycoproteim (NGPs) on the activity of the acetylcholinesterase (ACE) and GABA transferase involved in the rat brain mediator system. Disturbances in the neuromediator system may play an important role in the appearance of disturbances in the activity of the central nervous system (CNS), besides which, with an inadequate supply of iodine to the organism, hypothyroidism and also the