New Acetylene-Based Histamine H3 Receptor Antagonists Derived from the Marine Natural Product Verongamine
1998
New histamine H3 receptor antagonists were developed using an acetylene moiety as a replacement for the amide-oxime functionality of verongamine 5. Optimization of receptor binding was performed by following aliphatic Topliss tree guidelines. These new H3 ligands demonstrate excellent blood-brain barrier penetration.
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