Nucleomimetic strategy for the inhibition of HIV-1 nucleocapsid protein NCp7 activities.

Abstract We report the synthesis and biological properties of three modified dinucleotides T∗G , G∗T and T∗T in which the natural phosphodiester linkage has been replaced by a methylene carboxamide unit. They have been designed to act as nucleomimetics of a sequence recognized by the HIV-1 nucleocapsid protein NCp7 and to inhibit this interaction.