Abstract TMP112: Left Atrial Enlargement is Associated With Anticoagulation Failure in Patients With Acute Ischemic Stroke and Atrial Fibrillation

Background: Biomarkers to predict anticoagulation failure in patients with atrial fibrillation (AF) may help identify high-risk AF patients for further study. We hypothesize that left atrial enlargement (LAE) is more prevalent in AF patients admitted with ischemic stroke who are therapeutic, as opposed to non-therapeutic (NT), on anticoagulation. Methods: We included consecutive patients with AF admitted with a diagnosis of ischemic stroke between April 1st, 2015 and December 31st, 2016. Patients were divided into two groups based on whether they were therapeutic (warfarin with international normalized ratio ≥ 2.0 or non-vitamin K oral anticoagulant with uninterrupted use in the prior 2 weeks) vs. non-therapeutic on anticoagulation. We compared clinical and imaging characteristics, cardiac data (left atrial diameter on transthoracic echocardiogram), and outcomes (discharge modified Rankin Scale, discharge disposition, and symptomatic intracranial hemorrhage [sICH]) between the two groups. Multivariable lo...