1,1,1-および1,1,2-トリクロルエタンの血液中における減衰と呼気への排泄

: In order to investigate the diminution of 1, 1, 1-trichloroethane (1, 1, 1-TCE) and 1, 1, 2-trichloroethane (1, 1, 2-TCE) in the blood and the excretion of them by the lungs, 100 mg and 50 mg per kg body weight of 1, 1, 1-TCE were intravenously administered to 12 and 13 dogs, respectively, and the same amounts of 1, 1, 2-TCE to 5 and 8 dogs, respectively. The arterial blood gathered and the expired air collected by the time up to 60 minutes after the injection were analysed with a FID-gas-chromatography for the concentrations of the solvents. The results obtained are as follows. 1. Concentrations of 1, 1, 1-TCE in the blood were maintained significantly lower always from 2 to 60 minutes after the injection than those of 1, 1, 2-TCE. 2. While highest concentrations of the solvents in the expired air were found about 1 minute after the injection for both 1, 1, 1-and 1, 1, 2-TCE, values 1 minute after for the former were seven to ten times higher than those for the latter. However, no significant differences in the concentration were seen between both solvents after 15-40 minutes of administration in the expired air. 3. Ratios of the amounts expired by the lungs during 60 minutes after the injection to the total were 61-68% for 1, 1, 1-TCE, whereas only 21-32% for 1, 1, 2-TCE, respectively. 4. Highly significant linear regression was found between the concentrations of the solvent in the blood and those in the expired air for each of 1, 1, 1- and 1, 1, 2-TCE.