Effect of unilateral nephrectomy on the pharmacokinetics of rolitetracycline in rabbits.

: An analysis of the single-dose pharmacokinetics of rolitetracycline in rabbits after unilateral nephrectomy is presented. Rolitetracycline was injected i.v. 3.5 mg/kg before operation and after 2 weeks, 3 months and 6 months from unilateral nephroctomy. The concentration of the antibiotic in plasma was estimated by the fluorimetric method of Kohn. The two-compartment open model was applied to calculate rolitetracycline concentration changes. The calculations of pharmacokinetic parameters were performed using the Hewlett-Packard 9830B computer and fitting the concentrations of the antibiotic in blood to the general biexponential equation. AUC of rolitetracycline was increased in operated animals by 130% after 6 months. The mean kel at this time decreased, while t0.5 beta was prolonged from 1.0 h to 3.0 h. It is assumed that the dosage regimen of rolitetracycline should be changed in subjects possessing one kidney.