Vasomotor arterial endothelial dysfunction and hyperhomocysteinemia as diastolic heart failure progression risk factors in case of carbohydrate metabolism disorders

Aim. To evaluate significance of hyperhomocysteinemia and arterial endothelial dysfunction in the progression of diastolic heart failure in case of carbohydrate metabolism disorders. Methods. The study included 134 patients (63 men and 71 women), mean age - 59.3±4.7 years. The first group included patients with ischemic heart disease associated with type 2 diabetes mellitus (n=46). The second group included patients with type 2 diabetes mellitus and hypertension (n=48). The control group (n=40) included healthy volunteers without carbohydrate metabolism disorders and history of cardiovascular diseases. Results. Homocysteine concentration was 19.7±5.2 mmol/l in patients with type 2 diabetes mellitus, and was significantly higher than in the control group - 10.77±3.9 mmol/l (p Conclusion. Endothelial dysfunction leads to failure of regulatory mechanisms, contributes to the formation and progression of cardiovascular events: myocardial ischemia and left ventricular diastolic dysfunction in patients with diabetes mellitus associated with the hyperglycemia and hyperhomocysteinemia.