WTX is rarely mutated in acute myeloid leukemia.

WTX (Wilms’ tumor gene on the X chromosome) is inactivated in 30% of Wilms’ tumors, mostly by chromosomal deletion.[1][1] The WTX protein is a component of the β-catenin destruction complex and promotes its ubiquitination and degradation, functioning as a negative regulator of WNT/β-catenin