Id2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease

Masaki Miyazaki,Kazuko Miyazaki,Shuwen Chen,Manami Itoi,Marina Miller,Li-Fan Lu,Nissi M. Varki,Aaron N. Chang,David H. Broide,Cornelis Murre

Id2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease

2014

Masaki Miyazaki
Kazuko Miyazaki
Shuwen Chen
Manami Itoi
Marina Miller
Li-Fan Lu
Nissi M. Varki
Aaron N. Chang
David H. Broide
Cornelis Murre

Regulatory T (Treg) cells are needed to suppress autoreactive immune cell responses. Murre and colleagues show the transcriptional regulators Id2 and Id3 are necessary for proper Treg cell development, homing and maintenance.

Keywords:

Regulation of gene expression
Immunology
Interleukin 10
Inflammation
Cell biology
Regulatory T cell
Biology
Cell
Cell growth
Cellular differentiation
Immune system

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