Enantioselective Iridium-CatalyzedAllylic Aminations of Allylic Carbonates with Functionalized SideChains. Asymmetric Total Synthesis of (S)-Vigabatrin

Iridium-catalyzed aminations of allylic carbonates containing a variety of O-functional groups have been explored. High degrees of regio- as well as enantioselectivity were achieved with diacylamides under salt-free conditions and with arylamines. The results allowed the antiepilepsy drug (S)-vigabatrin to be prepared via a very short route.