AB033. Novel roles of mitochondrial outer membrane proteins in the maintenance of androgen receptor protein stability, resistance to anti-androgen receptor agents and progression of prostate cancer

Background Anti-androgen/androgen receptor (AR) agents, as the first-line hormone therapy, have been commonly administrated in prostate cancer (PCa) patients. However, the response of patients to these agents is temporary, the diseases inevitably developed to the androgen-refractory stage, and lost the response to these agents. In this current study, we investigated the novel roles of mitochondrial outer membrane (TOM) proteins in the maintenance of AR protein stability, and the development of resistance to anti-AR agents through mitochondria-mediated cell stress, and the activation of cell survival signaling pathways.