Effect of Ubiquinone Q10 and Antioxidant Vitamins on Free Radical Oxidation of Phospholipids in Biological Membranes of Rat Liver

We studied the effects of 30-day peroral treatment with β-carotene, a complex of antioxidant vitamins (vitamins C and E and provitamin A) and selenium, and solubilized ubiquinone Q10 on the antioxidant potential in rat liver (ascorbate-dependent free radical oxidation of unsaturated membrane phospholipids). β-Carotene irrespective of the administration route increased antioxidant potential of the liver by 2–3.5 times. The complex of antioxidant vitamins and selenium increased this parameter by more than 15 times. Antiradical activity in rat liver was extremely high after administration of solubilized ubiquinone Q10 (increase by more than by 36 times). It can be expected that reduced ubiquinone Q10in vivo should produce a more pronounced protective effect due to activity of the system for bioregeneration of this natural antioxidant.