Cysteine and methionine linked by carbon pseudopeptides inhibit farnesyl transferase

Compounds in which cysteine and methionine have been linked by amino acids replacing the A1A2 portion of the CA1A2X box template inhibit farnesyl and geranylgeranyl transferases. The expected specificity for FTase over GGTase I is observed. A variety of linkers are accepted with the most potent compounds possessing a hydrophobic substituent at C-2 of the A1A2 replacement.