Metallic Copper Wire: A Simple, Clear and Reusable Catalyst for the CuAAC Reaction in Supercritical Carbon Dioxide.

An efficient protocol for the CuAAC reaction catalyzed by metallic copper wire for the synthesis of 1,4-disubstituted triazoles has been developed in supercritical carbon dioxide (scCO2) at 50 °C. The protocol could afford the corresponding products in excellent yields with a very easy work-up procedure. The metallic copper wire could be reused for more than 200 runs without decreasing the catalytic efficiency.