Tratamiento antimicótico combinado: ¿para todos los pacientes y para cualquier micosis?

• To be of value, a combination must be more effective, show reduced toxicity, or cost significantly less than each component. • Statistical significance should support biological significance, i.e. a 10% reduction of morbidity/mortality, even if significant statistically, may not be worth routinely raising the cost of treatment form $100/day to thousands of dollars/day. Alternatively, a marked reduction of mortality/morbidity (e.g. 50%) may be well worth additive costs.