Polyfunctional macroheterocycles. 1. Synthesis of sulfur-containing macroheterocycles with endocyclic amido or sulfonamido groups

The reaction of 1,8-diamino-, 1,8-bis(2-carbomethoxyethylamino)-, and 1,8-bis(2-phenylethylamino)-3,6-dithiaoctanes and 1,2-bis(2-aminoethylthiomethyl)-4,5-dimethylbenzene with adipic, phthalic, and terephthalic acid dichlorides leads to the corresponding sulfur-containing macrocyclic diamines. Macrocycles that contain endocyclic sulfonamido groups are formed in the reaction of benzene-1,3-disulfonic acid dichloride with hexamethylenediamine and 1,8-bis(2-carbomethoxyethylamino)-3,6-dithiaoctane. The oxidation of 9,10-benzo-8,11-dioxo-7,12-bis-(2-carbomethoxyethyl)-1,4-dithia-7,12-diazacyclotetradec-9-ene with 30% hydrogen peroxide was studied.