mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer

Amaia Zabala-Letona,Amaia Arruabarrena-Aristorena,Natalia Martín-Martín,Sonia Fernández-Ruiz,James D. Sutherland,Michelle F. Clasquin,Julen Tomás Cortazar,J. M. Jimenez,I. Torres,Phong Quang,Pilar Ximénez-Embún,Ruzica Bago,Aitziber Ugalde Olano,Ana Loizaga-Iriarte,Isabel Lacasa Viscasillas,M. Unda,Verónica Torrano,Diana Cabrera,Sebastiaan van-Liempd,Ylenia Cendón,Elena Castro,Stuart Murray,Ajinkya Revandkar,Andrea Alimonti,Yinan Zhang,Amelia Barnett,Gina Lein,David Pirman,Ana R. Cortazar,Leire Arreal,Ludmila Prudkin,Ianire Astobiza,Lorea Valcarcel-Jimenez,Patricia Zúñiga-García,Itziar Fernández Domínguez,Marco Piva,Alfredo Caro-Maldonado,Pilar Sanchez-Mosquera,Mireia Castillo-Martin,Violeta Serra,Naiara Beraza,Antonio Gentilella,George Thomas,Mikel Azkargorta,Felix Elortza,Rosa Farràs,David Olmos,Alejo Efeyan,Juan Anguita,Javier Muñoz,Juan M. Falcon-Perez,Rosa Barrio,Teresa Macarulla,José M. Mato,María Luz Martínez-Chantar,Carlos Cordon-Cardo,Ana M. Aransay,Kevin R Marks,José Baselga,Josep Tabernero,Paolo Nuciforo,Brendan D. Manning,Katya Marjon,Arkaitz Carracedo

mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer

2017

Amaia Zabala-Letona
Amaia Arruabarrena-Aristorena
Natalia Martín-Martín
Sonia Fernández-Ruiz
James D. Sutherland
Michelle F. Clasquin
Julen Tomás Cortazar
J. M. Jimenez
I. Torres
Phong Quang
Pilar Ximénez-Embún
Ruzica Bago
Aitziber Ugalde Olano
Ana Loizaga-Iriarte
Isabel Lacasa Viscasillas
M. Unda
Verónica Torrano
Diana Cabrera
Sebastiaan van-Liempd
Ylenia Cendón
Elena Castro
Stuart Murray
Ajinkya Revandkar
Andrea Alimonti
Yinan Zhang
Amelia Barnett
Gina Lein
David Pirman
Ana R. Cortazar
Leire Arreal
Ludmila Prudkin
Ianire Astobiza
Lorea Valcarcel-Jimenez
Patricia Zúñiga-García
Itziar Fernández Domínguez
Marco Piva
Alfredo Caro-Maldonado
Pilar Sanchez-Mosquera
Mireia Castillo-Martin
Violeta Serra
Naiara Beraza
Antonio Gentilella
George Thomas
Mikel Azkargorta
Felix Elortza
Rosa Farràs
David Olmos
Alejo Efeyan
Juan Anguita
Javier Muñoz
Juan M. Falcon-Perez
Rosa Barrio
Teresa Macarulla
José M. Mato
María Luz Martínez-Chantar
Carlos Cordon-Cardo
Ana M. Aransay
Kevin R Marks
José Baselga
Josep Tabernero
Paolo Nuciforo
Brendan D. Manning
Katya Marjon
Arkaitz Carracedo

mTOR complex 1 signalling regulates polyamine metabolism and thereby promotes tumorigenesis, through regulation of the stability of a key enzyme, AMD1.

Keywords:

Enzyme
Polyamine metabolism
mTORC1
MTOR complex
Carcinogenesis
Prostate cancer
Biochemistry
Cancer research
Biology
Cell biology
Enzyme activator
Metabolic pathway
Polyamine
PI3K/AKT/mTOR pathway
Cancer
Cancer cell

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations