Least Glucose Variability Is Observed with the Combination of a GLP-1 Receptor Agonist and Basal Insulin Among Four Commonly Used Insulin Regimen in Type 2 Diabetes (VARIATION Study)

Age in years 65 (11) 60 (9) 64 (9) 61 (9) HbA1c prior to CGMS (%) 7.0 (0.4) 7.0 (0.2) 7.0 (0.4) 7.0 (0.4) BMI in kg/m 28.1 (5.5) 32 (5) 30.7 (5) 29.8 (4) Duration of diabetes in years 16 (10) 15 (9) 19 (7) 18 (8) Selfreported hypoglycemia during CGM period Any hypoglycemia ( 3.9 mmol/L) 5 incidences 5 incidences 12 incidences 40 incidences* Severe hypoglycemia ( 3.0 mmol/L) 1 incidence 0 incidence 1 incidence 10 incidences CGM data Daily measure Daily average SD (mmol/L) 2.0(0.6) 1.7(0.5) 2.0(0.5) 2.2(0.5) CGM data Daily measure Hypoglycemia Daily Frequency 0.3(0.5) 0.1(0.6) 0.3(0.7) 0.4(0.3) Percentage of timey 1.6(4) 1.9(5) 1.6(3) 2.6(3) CGM data Daily measure Hyperglycemia Daily Frequency 2.2(0.6) 2.4(0.6) 2.4(0.7) 2.2(0.6) Percentage of timey 39(16) 42(21) 51(17) 42(18)