Synthèse formelle de la (±)-physostigmine

Abstract The synthesis of 3-cyanomethyl-1,3-dimethyl-5-methoxyindol-2-one 2 , a precursor for physostigmine 1 , was achieved from ethyl 2-cyano-2-(1-carboethoxy-5-methoxy-3-indolyl)acetate 3a .