Synthesis of highly deuterium-labeled (R)-K-13675, PPAR α agonist, for use as an internal standard for low-level quantification of drugs in plasma

Abstract Two highly deuterium-labeled compounds, ( R )-K-13675- d 11 and ( R )-K-13675- d 7 , were prepared for use as internal standards for low-level quantification of plasma drugs by LC/MS/MS. We successfully demonstrated their utility in pharmacokinetic studies for sensitive and precise drug quantification.