Evaluation of Cytotoxicity, Acute Toxicity, Genotoxicity, Mutagenic and Antimutagenic Potential of Elaeocarpus Serratus L. Fruit Extract

Elaeocarpus serratus L. (Ceylon olive) fruits in popular medicine are used in the treatment of dysentery and diarrhea. Despite the properties of the fruit, there are no records in Brazil of studies that validate its safe use. The study aimed to evaluate the cytotoxicity, acute toxicity, genotoxicity, mutagenic, and antimutagenic potential of the aqueous extract of the fruits of E. serratus (AEES) through the platelet viability assay (MTT assay), acute toxicity test, micronucleus test and comet assay in rodents, and through the SMART assay with Drosophila melanogaster. It has shown moderate cytotoxic properties, the estimated LD50 of the AEES is greater than 2000 mg/kg and has no genotoxic potential in peripheral blood cells or clastogenic and aneugenic activity in cells from the bone marrow of rats. It is not a mutagenic agent and presents antimutagenic activity, attested by SMART assay.