Rational Design of a Chalcogenopyrylium-Based Surface-Enhanced Resonance Raman Scattering-Nanoprobe with Attomolar Sensitivity

Raman imaging offers great potential in biomedical imaging due to the combination of specificity and sensitivity. Here, the authors show nanoparticles functionalized with a chalcogenopyrylium reporter molecule, giving bright probes with low limits of detection for in vivo imaging.