Expression and recruitment of uracil-DNA glycosylase are regulated by E2A during antibody diversification.

Anders Wallenius,Jannek Hauser,Per Arne Aas,Antonio Sarno,Bodil Kavli,Hans E. Krokan,Thomas Grundström

Expression and recruitment of uracil-DNA glycosylase are regulated by E2A during antibody diversification.

2014

Anders Wallenius
Jannek Hauser
Per Arne Aas
Antonio Sarno
Bodil Kavli
Hans E. Krokan
Thomas Grundström

B-lymphocytes can modify their immunoglobulin (Ig) genes to generate specific antibodies with a new isotype and enhanced affinity against an antigen. Activation-induced cytidine deaminase (AID), wh ...

Keywords:

Transcription factor
Isotype
Antibody
Gene
Antigen
Uracil-DNA glycosylase
Cytidine deaminase
Molecular biology
Genetics
Immunoglobulin class switching
Biology
Regulation of gene expression

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations