Oral liquid preparation of ambroxol hydrochloride as well as preparation method and application of oral liquid preparation

2015 
The invention belongs to the field of a pharmaceutical preparation, and in particular relates to an oral liquid preparation of ambroxol hydrochloride as well as a preparation method and application of the oral liquid preparation. The oral liquid preparation consists of the following raw materials: 4-8 parts by weight of ambroxol hydrochloride, 200-300 parts by weight of glycerol, 100-200 parts by weight of sorbitol, 20-40 parts by weight of propylene glycol, 1-3 parts by weight of benzoic acid, 0.2-0.6 parts by weight of sucralose, 0.02-0.06 parts by weight of menthol, 0.2-0.4 parts by weight of essence, 0.05-1.20 parts by weight of EDTA-2Na and the balance of purified water to 100 parts by volume; by adding the EDTA-2Na and by replacing saccharin sodium with the sucralose, color change is reduced, and meanwhile the content of total impurities and the content of impurity B are reduced; and in addition, hidden dangers caused by the saccharin sodium are avoided, so that the stability of the medicine is improved, and the safety of the medicine in using is enhanced.
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