Symmetrical anhydride-type serine protease inhibitors: Structure-activity relationship studies of human chymase inhibitors
1999
Abstract We prepared a potent and relatively selective human chymase inhibitor 9 (−), based on the study of SAR of a symmetrical anhydride-type serine protease inhibitor 1 . Kinetic studies suggested that 9 (−) reacts with the Ser residue at the active site of the enzyme, forming a stable acyl enzyme complex. We also showed the importance of the tri-substituted β-amino acid structure for the potent anti-enzymatic activity.
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