Isolation of herpes simplex virus in chronic meningoencephalitis

: Virological examination of a patient suffering from chronic meningoencephalitis was carried out using serological and morphological methods. Strains of herpes simplex virus were isolated from the saliva, cerebrospinal fluid, and blood of the patient simultaneously in white mice and tissue culture. A rise in antibody titers to the isolate, its high neuropathogenicity in animal inoculation experiments, and the results of pathomorphological studies confirm the herpetic nature of the neuroinfection in this patient. Serological identification and investigation of biological properties of the virus showed it to belong to the 2nd antigenic type of herpes simplex virus.