Effects of Flavonoids from Sophora Japonica Thunb on Diabetes Mellitus in Mice

Objective: To investigate the hypoglycemic effect of flavonoids from Sophora japonica L. and its mechanism. Method: The model of hyperglycemia induced by streptozotocin was injected into the tail vein of the mice. The rats were fasted for 12 hours on the 11th day of injection and the fasting blood glucose. The total flavonoids of Sophorae japonicus were continuously fed for 30 days. Blood glucose and glycogen content were measured at the 10th, 20th and 30th day after administration. Take the formalin fixed pancreas, do histopathology. Result: The total flavonoids of Sophora japonica significantly reduced the hyperglycemia of streptozotocin-induced diabetic mice, improved the shape and function of pancreatic islet cells, and played a good role in lowering blood glucose. Conclusion: Flavonoids of Sophora japonica L. have obvious hypoglycemic effect, which can improve hyperlipidemia and kidney damage of diabetes mellitus.