Study on the relationship between clusterin and Survivin, proliferating cell nuclear antigen, Ki-67 in pancreatic adenocarcinoma

Objective To investigate the correlation between clusterin and inhibitor of apoptosis protein,proliferation markers in pancreatic adenocarcinoma.Methods Double fluorescent staining was employed to detect the expression of clusterin,Survivin,proliferating cell nuclear antigen (PCNA) and Ki-67 in 17 cases of pancreatic adenocarcinoma.Results The numbers of positive cells of clusterin and Survivin were 420 and 72 respectively.Among them,58 were both positive reaction of clusterin and Survivin.However,co-expression was undetected between clusterin and PCNA,Ki-67 in the any cancer cells.Conclusion Clusterin has a wider range than Survivin for anti-apoptosis in pancreatic adenocarcinoma.However,there was no significant association between expression of clusterin and cell proliferation. Key words: Pancreatic adenocarcinoma;  Clusterin;  Survivin ;  Proliferating cell nuclear antigen;  Ki-67